John William Lowery (born July 31, 1970), best known by the stage name John 5, is an American guitarist. His stage name was bestowed on him in 1998 when he left David Lee Roth's solo band and joined the rock group Marilyn Manson as their guitarist, taking over for Zim Zum.

Still going by the name John 5, Lowery became the guitarist for Rob Zombie in addition to his continued collaborations with musical artists across many genres. In 2022, John 5 left Rob Zombie and became the touring lead guitarist for Mötley Crüe.

He is also a solo artist having recorded ten guitar albums: Vertigo (2004), Songs for Sanity (2005), The Devil Knows My Name (2007), Requiem (2008), The Art of Malice (2010), God Told Me To (2012), Careful With That Axe (2014), Season of the Witch (2017), Invasion (2019), and Sinner (2021). He also has a remix album, Remixploitation (2009), and live albums It's Alive (2018) and Live Invasion (2020).

As a staff writer for Chrysalis Records, he works with artists such as Avril Lavigne, Rob Halford, k.d. lang, Garbage, Meat Loaf, Scorpions, Ozzy Osbourne, Slash, FeFe Dobson, and Steve Perry, and has written and recorded with Southern rock band Lynyrd Skynyrd.